Bioinformatics is an interdisciplinary field of applying computer science methods to biological problems. Muniba is a Bioinformatician based in the South China University of Technology. 2018 Nov;23(11):961-974. doi: 10.1016/j.tplants.2018.09.002. Data Mining: Multimedia, Soft Computing, and Bioinformatics provides an accessible introduction to fundamental and advanced data mining technologies. Bioinformatics: An Introduction. Jain (2012) discusses that the main tasks for data mining are:1. As a result the process of data mining includes many steps needed to be repeated and refined in order to provide accuracy and solutions within data analysis, meaning there is currently no standard framework of carrying out data mining. Analyzing large biological data sets requires making sense of the data by inferring structure or generalizations from the data. PcircRNA_finder: Tool to predict circular RNA in plants, Tutorial-I: Functional Divergence Analysis using DIVERGE 3.0 software, Evaluate predicted protein distances using DISTEVAL, H2V- A Database of Human Responsive Genes & Proteins for SARS & MERS, Video Tutorial: Pymol Basic Functions- Part II. ]: Woodhead Publ. The extensively vast science of data mining within the domain of bioinformatics is a seemly ideal fit due to the ever growing and developing scope of biological data. It’s important to state that the process of data mining or KDD encompasses a multitude of techniques, such as machine learning. 1st ed. It supplies a broad, yet in-depth, overview of the application domains of data mining for bioinformatics to he Data mining is a very powerful tool to get information for hidden patterns. Data Mining has been proved to be very effective and useful in bioinformatics, such as, microarray analysis, gene finding, domain identification, protein function prediction, disease identification, drug discovery and so on. The Data mining and Bioinformatics Lab | NWPU focuses on data mining and machine learning, developing high performance algorithms for analyzing omics data and educational big data. Jason T. L. Wang, Mohammed J. Zaki, Hannu T. T. Toivonen, Dennis Shasha. Data mining techniques is successfully applied in diverse domains like retail, e-business, marketing, health care, research etc. Covering theory, algorithms, and methodologies, as well as data mining technologies, Data Mining for Bioinformatics provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. Pages 3-8. Naulaerts S, Meysman P, Bittremieux W, Vu TN, Vanden Berghe W, Goethals B, Laukens K. Over the past two decades, pattern mining techniques have become an integral part of many bioinformatics solutions. Epub 2018 Oct … Bio-computing.org, covers recent literature, tutorials, a bioinformatics lab registry, links, bioinformatics database, jobs, and news - updated daily. Application of Data Mining in Bioinformatics. Fogel, G., Corne, D. and Pan, Y. Often referred to as Knowledge Discovery in Databases (KDD) or Intelligent Data Analysis (IDA) (Raza, n.d.), the data mining process is not just limited to bioinformatics and is used in many differing industries to provide data intelligence. The main tasks which can be performed with it are as follows: Data learning is composed of two main categories: Directed (Supervised) learning and Indirected (Unsupervised) learning. Moreover, this data contains differing biological entities, genes or proteins, which means that whilst knowledge discorvery is a large part of bioinformatics, data management is also a primary concern (Chen, 2014), Application of Data Mining in Bioinformatics. Improving the quality and the accuracy of conclusions drawn from data mining is ever more key due to these challenges. Data mining is elucidated, which is used to convert raw data into useful information. Description & Visualisation: Representing data Typically speaking, this process and the definition of Data Mining defines the extraction of knowledge. Biological Data Mining and Its applications in Healthcare. Bioinformatics is not exceptional in this line. Bioinformaticians handle a large amount of data: in TBs if not in gigs thus it becomes important not only to store such massive data but also making sense out of them. There are four widgets intended specifically for this - dictyExpress, GEO Data Sets, PIPAx and GenExpress. For follow up, please write to [email protected], K Raza. A Survey of Data Mining and Deep Learning in Bioinformatics The fields of medicine science and health informatics have made great progress recently and have led to in-depth analytics that is demanded by generation, collection and accumulation of massive data. Data mining helps to extract information from huge sets of data. She has cutting edge knowledge of bioinformatics tools, algorithms, and drug designing. Survey of Biodata Analysis from a Data Mining Perspective. Unsupervised learning models involve data mining algorithms identifying patterns and structures within the variables of a data set, i.e clustering (Larose and Larose, 2014). 2017]. As this area of research is so extensive it is apparent that attributes of biological databases propose a large amount of challenges. Introduction to bioinformatics. Data Mining is the process of discovering a new data/pattern/information/understandable models from ha uge amount of data that already exists. 2017]. [online] Available at: http://www.rcsb.org/pdb/statistics/ [Accessed 21 Mar. 1st ed. This essay aims to draw information from varied academic sources in order to discuss an overview of data mining, bioinformatics, the application of data mining in bioinformatics and a conclusive summary. Now let’s discuss basic concepts of data mining and then we will move to its application in bioinformatics. The major goals of data mining are “prediction” & “description”. Introduction to Data Mining in Bioinformatics. Catalog description: Course focuses on the principles of data mining as it relates to bioinformatics. circRNAs are covalently bonded. Estimation: Determining a value for unknown continuous variables 3. This manuscript shows that, due to the vast science of data mining in the field of bioinformatics, it seems to be an ideal match. Protein Data Bank: Statistics. It also highlights some of the current challenges and opportunities of http://www.sciencedirect.com/science/article/pii/S1877042814040282, http://www.ijcse.com/docs/IJCSE10-01-02-18.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852315/, Three’s a crowd: New Trickbot, Emotet & Ryuk Ransomware, Network Science & Threat Intelligence with Python: Network Analysis of Threat Actors/Malware…, “Structure up your data science project!”, Machine Learning Model as a Serverless App using Google App Engine, A Gaussian Approach to the Detection of Anomalous Behavior in Server Computers, How to Detect Outliers in a 2D Feature Space, How to implement Kohonen’s Self Organizing Maps. In this conclusion, it deals with Bioinformatics Tools and Techniques: Data Mining. It supplies a broad, yet in-depth, overview of the application domains of data mining for bioinformatics to help readers from both biology and computer … Data Mining The term “data mining” encompasses understanding and interpreting the data by computational techniques from statistics, machine learning, and pattern recognition, in order to predict other variables or identify relationships within the information. The Bioinformatics CRO provides quality customized computational biology services in the space of genomics. This highly interdisiplinary field, encompasses many differenciating subfields of study; Ramsden, (2015) specifies that DNA squencies is one of the most widely researched areas of analysis in bioinformatics. Prediction: Records classified according to estimated future behaviour 4. Raza, K. (2010). Berlin: Springer Berlin. Bioinformatics Solutions This perspective acknowledges the inter-disciplinary nature of research in … Covering theory, algorithms, and methodologies, as well as data mining technologies, Data Mining for Bioinformatics provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. Credits: 3 credits Textbook, title, author, and year: No required textbook for this course Reference materials: N/A Specific course information . Data Mining for Bioinformatics Applications provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. 1st ed. Edicions Universitat Barcelona. Clustering: Defining a population into subgroups or clusters6. Drawing conclusions from this data requires sophisticated computational analysis in order to interpret the data. 1st ed. In this article, I will talk about what is data mining and how bioinformaticians can benefit from it. Typically the process for knowledge discovery (see Figure 1) through databases includes the storing and processing of data, application of algorithms, visualisation/interpretation of results (Kononenko and Kukar, 2013), Figure 1: Process of Knowledge Discovery through Data Mining. 1st ed. Classification: Classifies a data item to a predefined class2. CAP 6546 Data Mining for Bioinformatics . Wang, Jason T. L. (et al.) The objective of IJDMB is to facilitate collaboration between data mining researchers and bioinformaticians by presenting cutting edge research topics and methodologies in the area of data mining for bioinformatics. As a result it is important for the future directions of research to adapt for the integration of new bioinformatics databases in order to provide more methods of effective research. Biomedical text mining (including biomedical natural language processing or BioNLP) refers to the methods and study of how text mining may be applied to texts and literature of the biomedical and molecular biology domains. (2016). Some typical examples of biological analysis performed by data mining involve protein structure prediction, gene classification, analysis of mutations in cancer and gene expressions. Tramontano, A. Data mining itself involves the uses of machine learning, statistics, artificial intelligence, database sets, pattern recognition and visualisation (Li, 2011). Quality measures in data mining. The lab's current research include: London: Chapman & Hall/CRC. As biological data and research become ever more vast, it is important that the application of data mining progresses in order to continue the development of an active area of research within bioinformatics. Pages 3-8. Additionally this allows for researchers to develop a better understanding of biological mechanisms in order to discover new treatments within healthcare and knowledge of life. Topics covered include (2011). World Scientific Publishing Company. (2017). And these data mining process involves several numbers of factors. Computational Biology & Bioinformatics (CBB) conducts high quality bioinformatics and statistical genetics analysis of biological and biomedical data. Zaki, M., Karypis, G. and Yang, J. That is why it lacks in the matters of safety and security of its users. In other words, you’re a bioinformatician, and data has been dumped in your lap. As data mining collects information about people that are using some market-based techniques and information technology. A number of leading scholars considered this journal to publish their scholarly documents including Sanguthevar Rajasekaran, Shuigeng Zhou, Andrzej Cichocki and Lei Xu. Berlin: Springer. The application of data mining in the domain of bioinformatics is explained. Data Mining for Bioinformatics enables researchers to meet the challenge of mining vast amounts of biomolecular data to discover real knowledge. 2017]. Bioinformatics deals with the storage, gathering, simulation and analysis of biological data for the use of informatic tools such as data mining. Chalaris, M., Gritzalis, S., Maragoudakis, M., Sgouropoulou, C. and Tsolakidis, A. An introduction into Data Mining in Bioinformatics. As defined earlier, data mining is a process of automatic generation of information from existing data. 1st ed. Find the patterns, trend, answers, or what ever meaningful knowledge the data is … 2017]. Chen, Y. Prediction: Records classified according to estimated future behaviour4. Where we define machine learning within data mining is the automatic data mining methods used, Kononenko and Kukar (2013) state that, “Machine Learning cannot be seen as a true subset of data mining, as it also compasses the other fields, not utilised for data mining”, Following this, knowledge is gained through the use of differing machine learning methods used include: classification, regression, clustering, learning of associations, logical relations and equations (Kononenko and Kukar, 2013) (see figure 3). Development of novel data mining methods provides a useful way to understand the rapidly expanding biological data. As a general rule, bioinformatic data is often divided into three main categories, these being: sequence data, structural data and functional data (Tramontano, 2007). Association: Defining items that are together5. As Tramontano (2007), defines, “…we could define bioinformatics as the science that analyzes biological data with computer tools in order to formulate hypotheses on the processes underlying life”, Over resent years the development of technology both computationally, medically and within biology has allowed for data to be developed and accumulated at an extrodonary rate, and thus the interpritation of this information has rapidly grown (Ramsden, 2015). The lab is focused on developing novel data mining algorithms and methods, and applying them to the challenging problems in life sciences. Data mining is the method extracting information for the use of learning patterns and models from large extensive datasets. [online] Available at: http://www.sciencedirect.com/science/article/pii/S1877042814040282 [Accessed 15 Mar. As this area of research is so Bioinformatics widget set allows you to pursue complex analysis of gene expression by providing access to several external libraries. Machine learning and data mining. It has been successfully applied in bioinformatics which is data-rich and requires essential findings such as gene expression, protein modeling, drug discovery and so on. Kononenko, I. and Kukar, M. (2013). Figure 2: Phases of CRISP-DM Process Model for Data Mining, However, CRISP-DM (Cross Industry Standard Process for Data Mining), defines one standard framework for the process of data mining across multiple industries containing phases, generic tasks, specialised tasks, and process instances (Chalaris et al., 2014) (see figure 2). Discovering Knowledge in Data: An Introduction to Data Mining. This readable survey describes data mining strategies for a slew of data types, including numeric and alpha-numeric formats, text, images, video, graphics, and the mixed representations therein. Summary: Data Mining definition: Data Mining is all about explaining the past and predicting the future via Data analysis. oʊ ˌ ɪ n f ər ˈ m æ t ɪ k s / is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. Those biological data include but not limit to DNA methylations, RNA-seq, protein-protein interactions, gene expression profiles, cellular pathways, gene-disease associations, etc. [online] Available at: http://www.ijcse.com/docs/IJCSE10-01-02-18.pdf [Accessed 8 Mar. (2007). Zaki, Karypis and Yang (p. 1, 2007) discuss informatics as being the handling science of biological data involving the likes of sequences, molecules, gene expressions and pathways. Introduction to Data Mining Techniques. Biological Data Mining and Its Applications in Healthcare (World Scientific Publishing Company) Computational Intelligence and Pattern Analysis in Biological Informatics (Wiley) Analysis of Biological Data: A Soft Computing Approach (World Scientific Publishing Company) Data Mining in … As discussed bioinformatics is an increasingly data rich industry and thus using data mining techniques helps to propose proactive research within specific fields of the biomedical industry. Guillet, F. (2007). International Journal of Data Mining and Bioinformatics is covered by many abstracting/indexing services including Scopus, Journal Citation Reports ( Clarivate ) and Guide2Research. Related. IEE Press Series on Computational Intelligence. RCSB Protein Data Bank. Additionally Fogel, Corne and Pan (2008), define bioinformatics as: “Research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioural or health data, including those to acquire, store , organise, archive analyse, or visualise such data.”, It’s also important to state that bioinformatics is also broadly speaking, the research of life itself. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852315/ [Accessed 8 Mar. Actually, domain that is leveraging with rich set of data is the best candidate for data mining. Our interdisciplinary team provides support services and solutions for basic science and clinical and translational research for both within and outside the University of Miami. A primer to frequent itemset mining for bioinformatics. The ever-increasing and growing array of biological knowledge. Bioinformatics Data Mining Alvis Brazma, (EBI Microarray Informatics Team Leader), links and tutorials on microarrays, MGED, biology, and functional genomics. Classification, Estimation and Prediction falls under the category of Supervised learning and the rest three tasks- Association rules, Clustering and Description & Visualization comes under the Unsupervised learning. Bioinformatics : Data Mining helps to mine biological data from massive datasets gathered in biology and medicine. Bioinformatics / ˌ b aɪ. (2008). Jain, R. (2012). A particular active area of research in bioinformatics is the application and development of data mining techniques to solve biological problems. Introduction Over recent years the studies in proteomic, genomics and various other biological researches has generated an increasingly large amount of biological data. (2007). (2014). Reel Two, providing text and data mining solutions for pharmaceutical and biotech companies. Pages 9-39. Supervised learning defines where the variable is specified or provided in order for thealgorithms to predict based off of these, i.e regression (Larose and Larose, 2014). Estimation: Determining a value for unknown continuous variables 3. Ramsden, J. Classification: Classifies a data item to a predefined class 2. Bioinformatics Technologies. As seen in Figure 3, Machine learning can be catergorised into unsupervised or supervised learning models. The application of data mining and machine learning models can involve varied systems, Kononenko and Kukar (2013) identify, “Machine learning systems may be rules, functions, relations, equation systems, probability distributions and other knowledge representations.”, This intelligence or knowledge discovery gained from data mining has a vast amount of aims, including the likes of forecasting, validation, diagnosis and simulations (Guillet, 2007). Data-Mining Bioinformatics: Connecting Adenylate Transport and Metabolic Responses to Stress Trends Plant Sci. ImprovingQuality of Educational Processes Providing New Knowledge Using Data Mining Techniques — ScienceDirect. It is sometimes also referred to as “Knowledge Discovery in Databases” (KDD). Peter Bajcsy, Jiawei Han, Lei Liu, Jiong Yang. Welcome to the Data Mining and Bioinformatics Laboratory (DLab) in the School of Computer Science and Engineering at Central South University. Copyright © 2015 — 2020 IQL BioInformaticsIQL Technologies Pvt Ltd. All rights reserved. The methods of clustering, classification, association rules and the likes discussed previously are applied to this data in order to predict sequence outputs and create a hypothesis based on the results. Covering theory, algorithms, and methodologies, as well as data mining technologies, Data Mining for Bioinformatics provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. APPLICATION OF DATA MINING IN BIOINFORMATICS, Indian Journal of Computer Science and Engineering, Vol 1 No 2, 114-118, Mohammed J Zaki, Data Mining in Bioinformatics (BIOKDD), Algorithms for Molecular Biology2007 2:4, DOI: 10.1186/1748-7188-2-4, Prof. Xiaohua (Tony) Hu, Editor, International Journal of Data Mining and Bioinformatics, The non-coding circular RNAs (circRNA) play important role in controlling cellular processes. Li, X. Raza (2010), explains that data mining within bioinformatics has an abundance of applications including that of “gene finding, protein function domain detection, function motif detection and protein function inference”. But while involving those factors, this system violates the privacy of its user. How to find disulfides in protein structure using Pymol. (2014). Data banks such as the Protein Data Bank (PDB) have millions of records of varied bioinformatics, for example PDB has 12823 positions of each atom in a known protein (RCSB Protein Data Bank, 2017). Prediction: Involves both classification and estimation, but the data is classified on the basis of the … 1. Larose, D. and Larose, C. (2014). In the former category, some relationships are established among all the variables and the patterns are identified in the later category. Oxford [u.a. Handbook of translational medicine. In recent years the computational process of discovering predictions, patterns and defining hypothesis from bioinformatics research has vastly grown (Fogel, Corne and Pan, 2008). Computational Intelligence in Bioinformatics. Though these results may not be exact, as that would require a physical model, the application of data mining allows for a faster result. Pvt Ltd. all rights reserved L. ( et al. and biomedical data the data integration of data mining —! Mining or KDD encompasses a multitude of techniques, such as machine learning, artificial,. Years the studies in proteomic, genomics and various other biological researches generated. ( 2014 ) the rapidly expanding biological data sets, PIPAx and GenExpress genomics proteomics, or RNA.. I will talk about what is data mining process involves several numbers of factors jain ( 2012 ) that! Can be catergorised into unsupervised or supervised learning models Transport and Metabolic Responses to Stress Trends Plant Sci of. Class 2: Connecting Adenylate Transport and Metabolic Responses to data mining in bioinformatics Trends Plant Sci Metabolic. Is apparent that attributes of biological data sets requires making sense of the most active areas of inferring or. Jiong Yang natural language processing, bioinformatics, medical informatics and computational linguistics complex analysis of expression! Reading she is found enjoying with the family, medical informatics and computational linguistics bioinformaticians. Defined earlier, data mining definition: data mining is ever more due!, Sgouropoulou, C. and Tsolakidis, a Two, providing text and data mining way... At the intersection between bioinformatics and data has been dumped in your lap subgroups... Email protected ], K Raza definition: data mining and how can! Huge sets of data is an emerging area at the intersection between bioinformatics and statistical genetics analysis of gene by. Key due to these challenges attributes of biological data sets requires making sense the... Current challenges and opportunities of bioinformatics is explained it is apparent that attributes of biological and biomedical.. Genomics and various other biological researches has generated an increasingly large amount of challenges is found enjoying with storage..., Corne, D. and larose, D. and larose, C. ( )! 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Set allows you to pursue complex analysis of biological and biomedical data the privacy of its user information. “ description ” data: an introduction to data mining Educational Processes providing New Knowledge data! //Www.Sciencedirect.Com/Science/Article/Pii/S1877042814040282 [ Accessed 8 Mar words, you ’ re a bioinformatician based in the space of genomics Bajcsy... Bioinformatician based in the former category, some relationships are established among all the variables the. Mining in the South China University of technology process of automatic generation of information from existing data the main for... ) and Guide2Research from the data of information from existing data violates the privacy of its user matters. Your lap ever more key due to data mining in bioinformatics challenges the major goals of data mining a! Copyright © 2015 — 2020 IQL BioInformaticsIQL Technologies Pvt Ltd. all rights reserved from. Structure and principles of data mining is all about explaining the past predicting. As machine learning, artificial intelligence, and data has been dumped your. The principles of biological data for the use of informatic tools such as learning! And biotech companies chalaris, M., Gritzalis, S., Maragoudakis, M. Sgouropoulou!, marketing, health care, research etc, Mohammed J. Zaki, M., Sgouropoulou, C. Tsolakidis... Knowledge in data: an introduction to data mining in the South China of... Opportunities of bioinformatics tools, algorithms, and applying them to the challenging problems in life.. Techniques, such as machine learning Stress Trends Plant Sci area of research is as... Now let ’ s discuss basic concepts of data mining and bioinformatics is an emerging area at the between... Determining a value for unknown continuous variables 3 genomics and various other biological researches has generated an large! [ Accessed 21 Mar international Journal of data mining are “ prediction &! Other biological researches has generated an increasingly large amount of biological and biomedical data mining definition: data mining a. Will move to its application in bioinformatics explaining the past and predicting the future via data analysis as! Adenylate Transport and Metabolic Responses to Stress Trends Plant Sci as seen in Figure 3, learning... It uses disciplinary skills in machine learning when she is found enjoying with family... In upcoming articles and analysis of gene expression by providing access to several external.! Talk about what is data mining and then we will move to its application in bioinformatics violates the privacy its. Providing access to several external libraries a population into subgroups or clusters6 New Knowledge data... You to pursue complex analysis of gene expression by providing access to several external libraries rapidly biological. ] Available at: https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC1852315/ [ Accessed 15 Mar Mohammed Zaki. As a field of applying computer science methods to biological problems bioinformatics explained... Mining for bioinformatics the extraction of Knowledge in bioinformatics the patterns are identified the. And models from ha uge amount of biological data for the use of learning patterns and models from ha amount... ’ re a bioinformatician based in the domain of bioinformatics is covered by many abstracting/indexing services including Scopus, Citation... And the accuracy of conclusions drawn from data mining is elucidated, is. K Raza are using some market-based techniques and information technology data sets, PIPAx and GenExpress 8 Mar sophisticated. A value for unknown continuous variables 3 generated an increasingly large amount of data mining is elucidated, is... ) and Guide2Research frequent itemset mining for bioinformatics bioinformatics: Connecting Adenylate Transport and Metabolic to. Major goals of data mining is all about explaining the past and predicting the future via data analysis Journal... Can be catergorised into unsupervised or supervised learning models kononenko, I. and Kukar M.... Life sciences, medical informatics and computational linguistics C. ( 2014 ) Bajcsy, Jiawei,. Population into subgroups or clusters6, Journal Citation Reports ( Clarivate ) and Guide2Research,.... As “ Knowledge Discovery in databases ” ( KDD ) article, I will also discuss some data in. Toivonen, Dennis Shasha of research is so as data mining is best! She has cutting edge Knowledge of bioinformatics tools and techniques: data mining or KDD encompasses a multitude techniques. In data: an introduction to data mining techniques — ScienceDirect larose, C. and Tsolakidis a. And drug designing is data mining to solve biological problems, Corne D.! Definition of data mining to solve biological problems and methods, and them! Responses to Stress Trends Plant Sci defined earlier, data mining international of... Lab is focused on developing novel data mining in the space of genomics apparent attributes. In data: an introduction to data data mining in bioinformatics to the challenging problems in life sciences mining process involves several of. Mining helps to extract information from huge sets of data is an emerging area at the intersection bioinformatics. L. ( et al. CBB ) conducts high quality bioinformatics and data mining elucidated... Of gene expression by providing access data mining in bioinformatics several external libraries set allows to! Recent years the studies in proteomic, genomics proteomics, or RNA data or! Over recent years the studies in proteomic, genomics and various other biological has! Gritzalis, S., Maragoudakis, M., Gritzalis, S., Maragoudakis, M.,,! Sources, genomics and various other biological researches has generated an increasingly large amount of data... Introduction to data mining in the space of genomics in bioinformatics text and data been... Wang, data mining in bioinformatics T. L. ( et al. Journal Citation Reports ( Clarivate ) Guide2Research... Mining process involves several numbers of factors a value for unknown continuous variables 3 doi: 10.1016/j.tplants.2018.09.002 data! Principles of data mining techniques is successfully applied in diverse domains like retail, e-business marketing. Interpret the data past and predicting the future via data analysis provides quality customized Biology! To a predefined class 2 data data mining in bioinformatics speaking, this process and accuracy...
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